Table 2 A dichotomous EXO106 score is predictive of initial biopsy results

From: A molecular signature of PCA3 and ERG exosomal RNA from non-DRE urine is predictive of initial prostate biopsy result

Any cancer, intended use, low volume

 

Biopsy result

      
 

Biopsy negative

Biopsy postitive

Total

Performance

s.e.

95% CI

Exo106 ⩽cut point

57

22

79

NPV %

72.15

5.04

62.27

82.04

Exo106 >cut point

49

67

116

PPV %

57.76

4.59

48.77

66.75

Total

106

89

195

     
 

Specificity %

Sensitivity %

      

Performance

53.77

75.28

 

NLR

0.46

   

s.e.

4.84

4.57

 

PLR

1.63

   

95% CI

44.28

66.32

      
 

63.27

84.24

      

High-grade cancer, intended use, low volume

 

Biopsy result

      
 

Biopsy negative or GL=6

GL⩾7

Total

Performance

s.e.

95% CI

Exo106⩽cut point

77

2

79

NPV %

97.47

1.77

94.00

100.00

Exo106>cut point

76

40

116

PPV %

34.48

4.41

25.83

43.13

Total

153

42

195

     
 

Specificity %

Sensitivity %

      

Performance

50.33

95.24

 

NLR

0.09

   

s.e.

4.04

3.29

 

PLR

1.92

   

95% CI

42.40

88.80

      
 

58.25

100.00

      
  1. Abbreviations: CI, confidence interval; NLR, negative likelihood ratio; NPV, negative predictive value; PLR, positive likelihood ratio; PPV, positive predictive value.
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