Abstract
Background:
The role of docetaxel chemotherapy in combination with androgen deprivation therapy for metastatic castrate-sensitive prostate cancer is emerging.
Methods:
We reviewed the results from the pivotal randomized phase III trials in this area: GETUG15, CHAARTED and STAMPEDE.
Results:
All three studies demonstrated a benefit in progression-free survival with the use of docetaxel. However, two of the studies demonstrated a clinically meaningful overall survival benefit (CHAARTED and STAMPEDE), whereas the GETUG15 study did not demonstrate a major benefit.
Conclusions:
Docetaxel is an important option to consider for men who are fit for chemotherapy with newly diagnosed metastatic prostate cancer commencing androgen deprivation therapy.
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CJS has consultancy with honoraria for Astellas, BIND therapeutics, Sanofi, Janssen, Genentech and Bayer. The remaining author declares no conflict of interest.
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Miller, R., Sweeney, C. Chemotherapy for metastatic castrate-sensitive prostate cancer. Prostate Cancer Prostatic Dis 19, 139–144 (2016). https://doi.org/10.1038/pcan.2016.10
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DOI: https://doi.org/10.1038/pcan.2016.10
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