Fig. 1: Intestinal failure (IF) patients with cholestasis exhibit alterations in bile acid (BA)-biotransforming bacteria and BA composition. | Experimental & Molecular Medicine

Fig. 1: Intestinal failure (IF) patients with cholestasis exhibit alterations in bile acid (BA)-biotransforming bacteria and BA composition.

From: Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling

Fig. 1

a Schematic depicting the roles of intestinal bacteria in BA metabolism. b, c The abundances of BA-biotransforming bacteria in the feces of patients with cholestasis (n = 16) were significantly lower than those in the feces of subjects without cholestasis (n = 16). d Changes in the BA composition in serum (without cholestasis, n = 26, with cholestasis, n = 20), feces (without cholestasis, n = 16, with cholestasis, n = 16) and liver tissue (without cholestasis, n = 12, with cholestasis, n = 8). *p < 0.05, **p < 0.01

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