Table 2 Bile acid profiles in the colonic content of mice (nmol/mg)

From: Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling

Bile acid (nmol/mg)

Untreated

GM

VCM

p valuea (GM vs. untreated)

p valuea (VCM vs. untreated)

7DHCA

16.49 ± 5.95

49.26 ± 71.74

0.76 ± 1.09

0.191

0.076

12DHCA

2.10 ± 1.23

1.99 ± 3.02

0.89 ± 1.32

0.922

0.357

3DHCA

1.65 ± 0.48

5.12 ± 6.23

0.40 ± 0.56

0.115

0.051

ωMCA

99.09 ± 74.65

19.22 ± 18.57

2.66 ± 5.99

0.007

0.029

α MCA

32.61 ± 15.67

13.99 ± 20.09

6.57 ± 10.65

0.043

0.366

βMCA

103.13 ± 101.17

109.10 ± 120.18

68.23 ± 103.94

0.911

0.468

HCA

4.03 ± 3.83

0.76 ± 0.64

0.24 ± 0.37

0.022

0.064

CA

38.44 ± 40.79

57.36 ± 225.41

46.20 ± 72.06

0.380

0.475

CDCA

2.79 ± 4.63

4.84 ± 11.20

3.99 ± 5.71

0.618

0.849

muroCA

4.20 ± 2.98

0.14 ± 0.17

0.11 ± 0.18

0.001

0.752

Total unconjugated primary BAs

304.53 ± 151.43

261.77 ± 474.62

130.05 ± 198.35

0.966

0.331

TωMCA

9.69 ± 8.50

1.89 ± 1.02

2586.99 ± 4881.97

0.015

0.132

TαMCA

2.76 ± 1.10

1.42 ± 0.90

13.97 ± 16.07

0.012

0.033

TβMCA

40.20 ± 31.75

2812.86 ± 890.14

8187.01 ± 1435.99

0.003

0.007

THCA

0.11 ± 0.08

6.96 ± 20.40

3.73 ± 6.35

0.329

0.674

TCA

4.08 ± 1.75

724.17 ± 2164.71

725.16 ± 1270.96

0.333

0.999

GCDCA

0.03 ± 0.02

0.06 ± 0.12

0.05 ± 0.02

0.567

0.818

GCA

0.05 ± 0.03

0.38 ± 1.10

0.10 ± 0.15

0.379

0.481

TCDCA

3.90 ± 2.25

51.22 ± 121.60

49.13 ± 63.79

0.260

0.966

Total conjugated primary BAs

60.82 ± 32.45

3598.96 ± 1593.35

11566.14 ± 2200.34

0.033

0.031

6ketoLCA

2.76 ± 2.06

0.35 ± 0.14

0.03 ± 0.04

0.003

0.000

7ketoLCA

1.35 ± 0.90

0.74 ± 2.52

0.27 ± 0.38

0.667

0.125

UDCA

12.98 ± 8.66

7.98 ± 13.85

3.94 ± 6.23

0.372

0.459

HDCA

16.78 ± 15.48

0.20 ± 0.19

0.25 ± 0.34

0.005

0.727

DCA

62.74 ± 38.62

0.25 ± 0.28

30.47 ± 116.53

0.000

0.019

Total unconjugated secondary/tertiary BAs

96.61 ± 51.15

10.52 ± 16.50

54.72 ± 46.00

0.000

0.019

TLCA

0.39 ± 0.41

0.05 ± 0.15

0.22 ± 0.44

0.032

0.301

TUDCA

1.27 ± 0.54

0.88 ± 0.59

137.22 ± 250.43

0.164

0.122

THDCA

0.90 ± 0.62

0.07 ± 0.20

0.85 ± 2.19

0.002

0.301

TDCA

6.12 ± 4.07

0.14 ± 0.29

0.43 ± 1.05

0.001

0.449

Total conjugated secondary/tertiary BAs

7.90 ± 5.07

1.14 ± 0.61

138.72 ± 252.73

0.001

0.140

  1. The data are the means ± SDs
  2. aOne-way ANOVA was used to compare differences between the GM vs. untreated groups and between the VCM vs. untreated groups
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