Table 2 Blocking STING-dependent innate immunity by RNA virus infection
From: STING signaling and host defense against microbial infection
Virus | Viral genes | Mechanisms | References |
|---|---|---|---|
HCV | NS4B | Disrupts the interaction between STING and TBK. | |
DENV | NS2B3 | Targets and cleavages wild type human STING to prevent type I IFN production. | |
NS2B | Targets cGAS to prevent mitochondrial DNA sensing released during DENV infection. | ||
ZIKV | NS2B3 | Cleaves R78 and G79 in the cytoplasmic loop of human STING. | |
NS1 | Recruits the deubiquitinase USP8 to cleave K11-linked ubiquitin chains of caspase-1 and the caspase-1 targets to cGAS for cleavage. | ||
IAV | FP | Interacts with STING to antagonize type I IFN production. |
