Fig. 1: Illustration depicting current findings on ApoExos.
From: Apoptotic cell-derived exosomes: messages from dying cells
Biogenesis of ApoExos begins with S1P/S1PR signals on the plasma membrane and requires caspase 3 for maturation of MVBs. ApoExos are associated with various pathophysiologic events, such as vascular homeostasis, autoimmunity and the resultant graft rejection, sterile inflammation, and proliferation and survival of tumors.
