Abstract
Objective
To investigate factors associated with development of severe retinopathy of prematurity (ROP) in extremely preterm (EP) infants.
Study design
This retrospective cohort study included 213 EP infants (22 + 0 to 27 + 6 weeks gestation) who were admitted to the neonatal intensive care unit of Osaka Women’s and Children’s Hospital between 2009 and 2017. Multivariable logistic regression analysis was used to identify neonatal factors associated with severe ROP requiring treatment.
Result
After adjustments for gestational age (GA), birth weight, sex, red blood cell transfusion, average SpO2, and fluctuations of SpO2 from birth to 32 weeks postmenstrual age, fluctuations of SpO2 (odds ratio [OR]: 2.10, 95% confidence interval [CI]: 1.03–4.27), and low GA (OR: 0.95, 95% CI: 0.91–0.98) were significantly associated with severe ROP.
Conclusions
Fluctuations of SpO2 from birth to 32 weeks postmenstrual age and low GA were significantly associated with development of severe ROP requiring treatment in EP infants.
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Acknowledgements
The authors thank Drs Masashi Hotta, Yasuka Kimoto, Eriko Iwasaki, Makoto Tamura, Kazue Morikawa, Natsuko Yamamichi, and the medical staff working in the neonatal intensive care unit at Osaka Women’s and Children’s Hospital for their support during this study. We thank Ryan Chastain-Gross, Ph.D., from Edanz Group (https://en-author-services.edanzgroup.com) for editing a draft of this manuscript.
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YI and KH conceptualized and designed the study, contributed to data analysis, and drafted the manuscript. MN, NM, SH, YF, YH, and KW reviewed results and gave conceptual suggestions. All authors reviewed the draft manuscript and approved the final manuscript.
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Imanishi, Y., Hirata, K., Nozaki, M. et al. Effect of fluctuation of oxygenation on the development of severe retinopathy of prematurity in extremely preterm infants. J Perinatol 40, 515–521 (2020). https://doi.org/10.1038/s41372-019-0571-y
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DOI: https://doi.org/10.1038/s41372-019-0571-y
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