Abstract
Objective
To compare the cognitive, language and motor scores of infants with severe BPD exposed to postnatal corticosteroids (PCS) and had early (ET), late (LT) or no tracheostomy (NT).
Methods
Retrospective study was designed to compare the developmental outcomes of 71 infants born between 2010 and 2017 with severe BPD exposed to PCS and had ET (≤122 days), LT (>122 days), or NT.
Results
Cognitive scores were lower in LT versus NT and ET (p = 0.050); motor scores were worse in LT versus NT and ET (p = 0.004). Dexamethasone use was higher in LT versus NT and ET (p = 0.040). Adjusted for PCS, odds for major cognitive impairment were 90% less in ET versus LT. Trend for improved language and motor outcomes was seen in ET versus LT.
Conclusion
Infants with severe BPD exposed to PCS and had ET had significantly better cognitive, and trend toward improved language and motor outcomes.
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Data availability
The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
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The authors thank the Medical Writing Center at Children’s Mercy Kansas City for their help in editing the manuscript.
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AT, GA and WM conceptualized and designed the study. AT collected the data. AT, GA, TG, JN and WM analyzed the data. AT wrote the first draft. GA, JN, TG and WM revised the manuscript. All authors approved the final manuscript prior to submission.
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Taha, A., Akangire, G., Noel-Macdonnell, J. et al. The impact of early tracheostomy on neurodevelopmental outcomes of infants with severe bronchopulmonary dysplasia exposed to postnatal corticosteroids. J Perinatol (2023). https://doi.org/10.1038/s41372-023-01864-5
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DOI: https://doi.org/10.1038/s41372-023-01864-5