Abstract
Objective
Nasal Intermittent Positive Pressure Ventilation (NIPPV) is an effective therapy for infants in respiratory distress. We here report the safety of a novel, low-cost, non-electric bubble NIPPV device in comparison with bubble NCPAP.
Study design
At Paramitha Children’s Hospital (Hyderabad, India), preterm (n = 60) neonates with moderate respiratory distress were pragmatically allocated to bubble NCPAP (5–8 cm H2O) or bubble NIPPV (Phigh 8–12 cm H2O/Plow 5–8 cm H2O) based on staff and equipment availability. Primary outcomes to assess safety included clinically relevant pneumothorax, nasal septal necrosis, or abdominal distention.
Results
One patient in each arm developed minor nasal septal injury (grade 3 on NCPAP, grade 2 on NIPPV); no patients in either arm developed a clinically significant pneumothorax or abdominal distention.
Conclusion
The similar rates of nasal septal injury, pneumothorax and abdominal distention suggest that bubble NIPPV has a similar safety profile as bubble NCPAP for preterm infants in respiratory distress.
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Data availability
The dataset analyzed during the current study is available from the corresponding author on reasonable request.
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Acknowledgements
This data has previously been presented at PRESS (Department of Pediatrics, University of Minnesota).
Funding
Research reported in this publication was supported by the Thrasher Foundation and by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1-TR002494.
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Contributions
Study Conception and Design (SJ, MG, VB, TS, SM), Data analysis (SJ, MG, MM, AB, PR, VB, TS, SM), Drafting of manuscript and approval of final manuscript (SJ, MG, MM, AB, PR, VB, TS, SM).
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Competing interests
SCJ is a co-inventor of bubble NIPPV technology and co-founder of AIM Tech Health.
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John, S.C., Garg, M., Muttineni, M. et al. Safety of bubble nasal intermittent positive pressure ventilation (NIPPV) versus bubble nasal continuous positive airway pressure (NCPAP) in preterm infants with respiratory distress. J Perinatol (2024). https://doi.org/10.1038/s41372-024-01904-8
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DOI: https://doi.org/10.1038/s41372-024-01904-8