Fig. 1

Absolute number of mutations in the study: a Left: absolute numbers of genes with at least one mutation of the specified class found in the study. Right: Number of patients carrying at least one mutation of the specified class. Oncogenic variants: light blue. Possible oncogenic variants: dark blue. Variants of unknown significance: orange. No variants identified: green. b Top: stacked bar chart of mutations in the study, limited to genes with >2 oncogenic mutations, broken down by mutation class. Bottom: For the same genes, missense variants are in red, truncating variants are in gray