Fig. 3

GluN2A receptors on PV-cells mediate rapid ketamine action. a Schematic of PV-Cre⁺/GluN2A^f/f mouse construction. b Ketamine-induced changes of maximal evoked response were abolished in PV-Cre⁺/GluN2A^f/f males (blue filled circle, n = 72, 6 mice) (% of pre-ketamine level, median ± 95% CI; asterisk refers to Friedman test with Dunn’s multiple comparison vs baseline; hash refers to Kruskal–Wallis with Dunn’s multiple comparison WT vs mutant). c Spectrogram comparison from WT at baseline (black trace) and 30 min post-ketamine (purple trace). Solid lines, mean of all mice; shaded areas, sem. Spectrogram calculated as a percentage of total power measured between 4 and 100 Hz (n = 6 mice). p-Value of two-way row matched ANOVA. Inset, quantification of γ-oscillations between 20–50 Hz and 25–35 Hz