Fig. 4 | Mucosal Immunology

Fig. 4

From: Herpes simplex virus-binding IgG traps HSV in human cervicovaginal mucus across the menstrual cycle and diverse vaginal microbial composition

Fig. 4

Ab-mediated trapping of HSV-1 as a function of microbial Community State Type (CST). Samples were sequenced with 16 s rRNA whole-genome sequencing analysis and classified into CSTs depending on the predominant microbial species, according to the following groups: Class I (L.crispatus, n = 18), Class II (L.gasseri, n = 4), Class III (L.iners, n = 22), Class IV (G.vaginalis, n = 16), or Class V (L.Jensenii, n = 6).23 After classification, HSV-1 mobility was compared for each Ab condition. a Ensemble-averaged <Deff> in CVM treated with different Ab and b percent fast-moving viruses (Deff) ≥ 0.347 µm2/s. Two-Way ANOVA with multiple comparisons (Tukey’s Multiple Comparison’s Test) (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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