Abstract
Background
In the United States of America (USA), prostate cancer (PC) is the most common cancer in men and the second cause of cancer mortality. Black men (BM) have a higher incidence and worse mortality when compared to white men (WM). We compared trends in PC mortality in the USA by race and state from 1999 to 2019.
Methods
We extracted PC mortality data from the Centers for Disease Control (CDC) WONDER database using the International Classification of Diseases (ICD) 10 code C61. Age-Standardized Mortality Rates (ASMR) were divided into racial groups and reported by year and state. Due to the lack of available data in many states, analyses were conducted only for WM and BM using Joinpoint regression for trend comparisons.
Results
Between 1999–2019, ASMR decreased at the national level in Black (−44.6%), Asian (−44.8%), White (−31.8%), and American Indian or Alaskan native men (−19.0%). ASMR decreased in all states for both races. The greatest drop in ASMR was in Kentucky (−47.0%) for WM and Delaware (−57.8%) for BM. In 2019, ASMRs in BM (13.4/100 000) were significantly higher than WM (7.3/100 000), American Indian or Alaskan Native (3.2/100 000), and Asian men (3.2/100 000) (p < 0.001). The highest ASMRs were in Nebraska (33.5/100 000) for BM and Alaska (11/100 000) for WM.
Conclusions
During the last 20 years, the PC mortality rate dropped in all states for all races, suggesting an advancement in management strategies. Although a higher decrease in ASMR was observed in BM, ASMR remain higher among BM. ASMRs were also found to be increasing in many states post USPSTF guideline change (2012), indicating a need for more education around optimized prostate cancer screening.
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Data availability
The datasets generated during and/or analyzed during the current study are available in the WONDER database, https://wonder.cdc.gov/
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Each of the authors significantly contributed to this manuscript. CJ, CM, NA, JS, JSH, and RRM made significant contributions to the concept and design of this paper. CJ, JS, and DM were significantly involved in the statistical analysis. CJ, CM, NA, CJ, JS, DM, HS, IS, JSH, and RRM extensively drafted the manuscript. RRM, IS, CJ, CM, RRA and JSH were involved in the critical revision of the manuscript and contributed important intellectual content. CJ (corresponding author, guarantor) takes responsibility for the manuscript’s content, including the data and analysis.
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Jani, C., Mouchati, C., Abdallah, N. et al. Trends in prostate cancer mortality in the United States of America, by state and race, from 1999 to 2019: estimates from the centers for disease control WONDER database. Prostate Cancer Prostatic Dis 26, 552–562 (2023). https://doi.org/10.1038/s41391-022-00628-0
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DOI: https://doi.org/10.1038/s41391-022-00628-0
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