Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: A systematic review of SARS-CoV-2 vaccine candidates

Fig. 3

NAbs against CoVs and the scheme of Reverse Vaccinology 2.0. a NAbs, such as mAbs, single-domain antibodies, scFvs, and Fabs, are able to target viral proteins, with RBD being the most potent target. This process may further block receptor binding and membrane fusion, commonly via targeting the S1 and/or S2 subunit. b The scheme of Reverse Vaccinology 2.0. Antibodies are isolated from convalescent patients and tested for their efficacy in vitro and in vivo. NAbs are further studied in complex with the antigen. Identifying the epitopes may aid in immunogen design, which will later be evaluated in animal models and humans

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