Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Eosinophil-derived chemokine (hCCL15/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation

Fig. 4

CCL6 deficiency abolishes the impairment of HSC homeostasis in allergen-induced airway inflammation. a Murine eosinophil differentiation hierarchy. b-c Quantitative number of eosinophils in peripheral blood (b) and bone marrow (c) of NS or OVA-challenged WT and Ccl6-/- mice. d-e Representative flow cytometric dot plots (d) and quantitative number (e) of LSK. f-g Representative flow cytometric dot plots (f) and quantitative number (g) of CMP, GMP, MEP. h, i Representative flow cytometric dot plots (h) and quantitative number (i) of EoP. Data are statistically calculated as mean ± SEM for 4–6 mice in each group from three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001 by one-way ANOVA with Sidak’s multiple comparisons test

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