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Clonal hematopoiesis of indeterminate potential in older patients having received an allogeneic stem cell transplantation from young donors

Bone Marrow Transplantation volume 55, pages 665–668 (2020)Cite this article

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Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the presence of a hematologic neoplasm-associated somatic mutation in peripheral blood (PB) or bone marrow (BM), but the absence of definitive morphological evidence of a hematologic neoplasm.

Genes most frequently mutated in CHIP are DNMT3A, TET2, and ASXL1 [1,2,3,4]. Mutations in these genes are also common in myelodysplastic syndromes (MDS) or acute myeloid leukemias (AML). The prevalence of CHIP increases with older age; it occurs in more than 10–25% of individuals older than 70 years [1,2,3,4,5,6]. CHIP associates with higher risk for the development of hematologic neoplasms or cardiovascular diseases (e.g., coronary artery disease (CAD) or stroke) [1,2,3, 7,8,9]. A causal relationship between CHIP and cardiovascular diseases is supported by mouse models [7, 10].

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Acknowledgements

The authors thank Irmgard Matt (Department of Medicine I, Medical Center – University of Freiburg) for providing the clinical information on the patients and PD Dr. Alexandra Nieters, University of Freiburg for the permission to use the PyroMark instrument. The research was supported by the Translational Research Training in Hematology (TRTH) of the European Hematology Association (EHA) and American Society of Hematology (ASH) (to HB), the German Research Foundation [DFG; FOR 2674 BE 6461/1-1 (to HB), LU 429/16-1 (to ML)], the German Cancer Aid [111210 (to HB)] and the Böhringer Ingelheim Foundation [Exploration Grant (to HB)].

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  1. These authors contributed equally: Anezka Heumüller, Julius Wehrle

Authors and Affiliations

  1. Department of Medicine I, Medical Center – University of Freiburg, Freiburg, Germany

    Anezka Heumüller, Julius Wehrle, Juliane Stosch, Christoph Niemöller, Sabine Bleul, Miguel Waterhouse, David Uhl, Michael Lübbert, Justus Duyster, Jürgen Finke & Heiko Becker

  2. Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Anezka Heumüller, Julius Wehrle, Juliane Stosch, Christoph Niemöller, Sabine Bleul, Miguel Waterhouse, David Uhl, Michael Lübbert, Justus Duyster, Jürgen Finke & Heiko Becker

  3. German Cancer Consortium (DKTK) Partner Site, Freiburg, Germany

    Julius Wehrle, Michael Lübbert, Justus Duyster & Heiko Becker

  4. Department of Medicine III, University Hospital, LMU Munich, Munich, Germany

    Klaus H. Metzeler

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  1. Anezka Heumüller
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Contributions

AH: conception and design; specimen acquisition and processing; next generation sequencing (NGS) data acquisition, analyses and interpretation; analysis coordination. JW: NGS data analyses and interpretation. JS: specimen processing; NGS and conventional sequencing data acquisition and analyses. CN: specimen processing; NGS and conventional sequencing data acquisition and analyses. SB: specimen processing; conventional sequencing data acquisition and analyses. MW: specimen acquisition and processing; chimerism data acquisition and interpretation. DU: conventional sequencing data acquisition and analyses. KHM: conception and design. ML: conception and design; patient care; specimen acquisition; data interpretation. JD: conception and design; data interpretation. JF: conception and design; patient care; specimen acquisition; data interpretation. HB: conception and design; patient care; specimen acquisition; data acquisition, analyses and interpretation; analysis coordination; manuscript preparation.

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Correspondence to Heiko Becker.

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Heumüller, A., Wehrle, J., Stosch, J. et al. Clonal hematopoiesis of indeterminate potential in older patients having received an allogeneic stem cell transplantation from young donors. Bone Marrow Transplant 55, 665–668 (2020). https://doi.org/10.1038/s41409-019-0575-4

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