Fig. 2

Network properties of GWAS cancer-risk SNPs. a Distribution of core scores for SNPs associated with increased cancer risk in skin by GWAS (in blue) and other skin SNPs (in grey). P-values were obtained by using a likelihood ratio test and pruning for SNPs in linkage disequilibrium. Distributions for all tissue-specific networks are shown in Supplementary Fig. S1. b An example of a SNP with high core score: rs72699833, in LD with rs11249433, a SNP associated with a higher risk to develop breast cancer. This SNP belongs to community 147 (top panel), which is enriched for breast cancer-risk SNPs and is associated with multiple genes involved in epithelium development. LGALS7B is represented here but belongs to another community (107). Details on the associations are provided in Supplementary Table S8. Dashed lines indicate association in trans, full line in cis. The thickness of the lines corresponds to the strength of the association. c Enrichment in Gene Ontology Terms for community 147 in the skin