Table 2 Triple-negative breast cancers cases: distribution according to miR-30a (5p and 3p) expression, demographics and clinical pathological features

From: A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness

  

miR-30a-5p

 

miR-30a-3p

 
 

Total (N=59)

Lowa (N=29)

Higha (N=30)

P-value

Lowa (N=29)

Higha (N=30)

P-value

Median follow-up (months)

63.2

61.0

65.4

0.87c

51.3

67.7

0.06c

Median age at diagnosis (yrs)

51

49

52

0.50c

52

50

0.13c

 

No. (%)

No. (%)

No. (%)

 

No. (%)

No. (%)

 

Tumor sizeb

 T1

28 (52.8)

12 (42.9)

16 (64.0)

0.09d

11 (39.3)

17 (68.0)

0.06d

 T2

22 (41.5)

13 (46.4)

9 (36.0)

 

14 (50.0)

8 (32.0)

 

 T3–T4

3 (5.7)

3 (10.7)

0 (0.0)

 

3 (10.7)

0 (0.0)

 

Lymph nodesb

 N0

28 (47.5)

10 (35.7)

18 (75.0)

0.01d

9 (32.1)

19 (79.2)

<0.001d

 N+

24 (40.7)

18 (64.3)

6 (25.0)

 

19 (67.9)

5 (20.8)

 

Metastasis

 M0

54 (91.5)

28 (96.6)

26 (86.7)

0.35d

27 (93.1)

27 (90.0)

1.00d

 M+

5 (8.5)

1 (3.5)

4 (13.3)

 

2 (6.9)

4 (10.0)

 

TNM stage

 I

19 (32.2)

8 (27.6)

11 (36.7)

0.80d

7 (24.1)

12 (40.0)

0.43d

 II

25 (42.4)

13 (44.8)

12 (40.0)

 

13 (44.8)

12 (40.0)

 

 III–IV

15 (25.4)

8 (27.6)

7 (23.3)

 

9 (31.0)

6 (20.0)

 

Tumor gradeb

 G1–G2

3 (5.1)

1 (3.6)

2 (6.7)

1.00d

0 (0.0)

3 (10.4)

0.24d

 G3

55 (93.2)

27 (96.4)

28 (93.3)

 

29 (100.0)

26 (89.7)

 

Radiation treatmentb

 No

23 (45.1)

10 (38.5)

13 (52.0)

0.40d

11 (45.8)

12 (55.6)

1.00d

 Yes

28 (54.9)

16 (61.5)

12 (48.0)

 

13 (54.2)

15 (44.4)

 

Pharmacological treatmentb

 No

9 (16.1)

3 (11.1)

6 (20.7)

0.47d

4 (14.8)

5 (17.2)

1.00d

 Yes

47 (83.9)

24 (88.9)

23 (79.3)

 

23 (85.2)

24 (82.8)

 

Drugsb

 Anthracycline

21 (47.7)

14 (60.9)

7 (33.3)

0.23d

11 (52.4)

10 (43.5)

0.73d

 Anthracycline/Taxanes

11 (25.0)

4 (17.4)

7 (33.3)

 

4 (19.0)

7 (30.4)

 

 CMF

12 (27.3)

5 (21.7)

7 (33.3)

 

6 (28.6)

6 (26.1)

 
  1. CMF cyclophosphamide, methotrexate and 5-fluorouracil
  2. aThe median value was used as cut-off
  3. bThe sum does not add up to the total because of some missing values
  4. cMann–Whitney–Wilcoxon test
  5. dFisher’s exact test