Fig. 2: The FKH domain of FOXP3 is essential for its interaction with Gal-1. | Cell Death & Disease

Fig. 2: The FKH domain of FOXP3 is essential for its interaction with Gal-1.

From: Nuclear galectin-1-FOXP3 interaction dampens the tumor-suppressive properties of FOXP3 in breast cancer

Fig. 2

a Schematic representation of full-length FOXP3 and corresponding truncated FOXP3 proteins (called F1-60, F61-140, F141-195, F196-230, F231-300, or F301-431). b HEK293T cells were transfected with corresponding Flag-tagged truncated FOXP3 and Gal-1. Co-IP experiment was performed using anti-Flag antibody. c HEK293T cells were transfected with Flag-tagged FOXP3 or Flag-tagged ΔFKH-FOXP3 and Gal-1. Co-IP experiment was performed using anti-Flag antibody. d Three-dimensional structure of FOXP3. The key residues of the FKH domain are shown in red. e A computational docking model shows the superimposition of Gal-1 (yellow) and FOXP3

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