Fig. 3: Skin wrinkles and hair loss in mtDNA-depleter mice
From: Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function
a mtDNA-depleter mice show skin wrinkles (ii), hair loss (ii), and kyphosis (iii) after 4–8 weeks of continuous dox-mediated induction. b–d Quantitative assessment of body weight (b), body length (c), and lean mass/length ratio (d) of mtDNA-depleter (n = 30) and wild-type control mice (n = 30). Data are expressed as mean ± s.e.m; *P<0.05, Student’s t test. e, f Quantitative assessment of hair loss (e) and wrinkled skin (f) phenotypic changes in mtDNA-depleter (n = 30) and wild-type control mice (n = 30) after 60 days of continuous dox induction
