Fig. 2: Inhibition of mitochondrial NCX1 by CGP-37157, but not membrane NCX1 by SN-6, attenuates the toxic effect of rotenone (Rot) plus α-synuclein (α-syn) in striatal slices. | Cell Death & Disease

Fig. 2: Inhibition of mitochondrial NCX1 by CGP-37157, but not membrane NCX1 by SN-6, attenuates the toxic effect of rotenone (Rot) plus α-synuclein (α-syn) in striatal slices.

From: Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity

Fig. 2

a Time course showing the field excitatory postsynaptic field potential (fEPSP) amplitude of striatal slices before and following 0.3 μM Rot application in control conditions (n = 10, open symbols), in the presence of 10 µM SN-6 (n = 4, green symbols); in slices incubated for 1 h with 3 nM α-syn (n = 10, filled symbols), or in presence of SN-6 in slices incubated for 1 h with α-syn (n = 4, cyan symbols) (SN-6+α-syn vs α-syn, two-way analysis of variance (ANOVA), group main factor F(1, 10) = 0.013, P > 0.05). Representative traces on the right show the fEPSP before (pre-Rot) and 40 min after the application of 0.3 µM Rot applied in striatal slices in different conditions. b Time course showing the fEPSP amplitude of slices before and following 0.3 μM Rot application in control conditions (n = 10, open symbols), in the presence of 3 µM CGP-37157 (n = 5, cyan symbols), in slices incubated for 1 h with α-syn 3 nM (n = 10, filled symbols), or in the presence of CGP-37157 in slices incubated for 1 h with α-syn (n = 6, red symbols) (CGP-37157+α-syn vs α-syn, two-way ANOVA, group main factor F(1, 20) = 7.853, **P < 0.01). Representative traces showing the fEPSP before (pre-Rot) and 40 min after the application of 0.3 µM Rot in different conditions

Back to article page