Fig. 6: BP-1-102 maintained LC3B expression and autolysosome in AAA tissues. | Cell Death & Disease

Fig. 6: BP-1-102 maintained LC3B expression and autolysosome in AAA tissues.

From: A novel STAT3 inhibitor attenuates angiotensin II-induced abdominal aortic aneurysm progression in mice through modulating vascular inflammation and autophagy

Fig. 6

a LC3B (green) expression in AAA tissues was investigated using immunofluorescence staining at indicated time points. α-SMA (red) was used to stain VSMCs. DAPI (blue) was used to stain cell nuclei. Saline treated group was used as control (mock). b TEM was used to investigate the ultrastructure of mitochondria (M), ASS (atuolysosome), AP (autophagosome) changes in VSMCs of aortic wall on day 28. AngII+ BP-1-102+ group (AngII+BP+, right panel) showed increased ASS comparing with AngII+ group (middle panel). N (nucleus), RER (endoplasmic reticulum), Go (Golgi apparatus). Saline treated group was used as control (mock) (left panel).

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