Fig. 7: POU2F2-PDPK1 axis promotes brain tumorigenesis by regulating glycolysis. | Cell Death & Disease

Fig. 7: POU2F2-PDPK1 axis promotes brain tumorigenesis by regulating glycolysis.

From: POU2F2 regulates glycolytic reprogramming and glioblastoma progression via PDPK1-dependent activation of PI3K/AKT/mTOR pathway

Fig. 7

A Orthotopic tumorigenesis abilities of LN229 cells with depletion of POU2F2 and restoration of PDPK1 (top) and survival rates of mice (below). B Subcutaneous tumorigenesis abilities of LN229 cells depleted of POU2F2 and restoration of PDPK1. C Immunohistochemical staining analysis of POU2F2, PDPK1, GLUT1, HK2, and PKM2 in tumor tissues formed by GBM cells depleted of POU2F2 and restoration of PDPK1. D The correlation of POU2F2 expression with PDPK1, GLUT1, and HK2 in TCGA patients’ data. E The correlation of POU2F2 expression with PDPK1, GLUT1 and HK2 in our local patients’ data. All data were shown as the mean ± SD, **p < 0.01. All p values were based on analysis control versus treatment.

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