Fig. 1: Strategies for rejuvenation or elimination of senescent cells. | Cell Research

Fig. 1: Strategies for rejuvenation or elimination of senescent cells.

From: A β-galactosidase kiss of death for senescent cells

Fig. 1

a Schematic diagram of strategies that rejuvenate or eliminate senescent cells via modulation of metabolic pathways and epigenetic reprogramming to a younger state, or induction of apoptosis, respectively. b Processing of the prodrug SSK1 by lysosomal β-gal into a cytotoxic compound elicits activation of the p38 MAPK apoptotic pathway and clearance of senescent cells.

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