Fig. 1: The BDNF homodimer binds to the second immunoglobulin-like domain of TrkB, thereby favoring a conformation of TrkB that leads to the phosphorylation of tyrosine residues by the kinase domain. | Cell Research

Fig. 1: The BDNF homodimer binds to the second immunoglobulin-like domain of TrkB, thereby favoring a conformation of TrkB that leads to the phosphorylation of tyrosine residues by the kinase domain.

From: A new molecular target for antidepressants

Fig. 1

Both cholesterol and antidepressants (AD) promote this configuration thereby potentiating BDNF signaling activity and synaptic plasticity.

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