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Acknowledgements
This work was supported by grants from the National Natural Science Foundation of China (32150023 to P.L.), the National Key R&D Program (2019YFA0508403 and 2023YFF1204703 to P.L.), the Natural Science Foundation of Xiamen, China (3502Z20227251 to Z.L.), Xiamen Ocean and Fisheries Development Special Funds Program (22CZP006HJ03 to Z.L.).
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P.L conceived the ideas. Z.L. and P.L supervised the project. W.J. performed cell biology and biochemical experiments. W.L. performed the selection of nanobody and affinity assay. W.J. wrote the manuscript. Z.L. and P.L. edited the manuscript. All authors have commented on and approved the manuscript.
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P.L. is the scientific co-founder of NuPhase Therapeutics, whose projects are not related to this work. Other authors declare that they have no other conflict of interest.
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Jia, W., Li, W., Li, Z. et al. An all-in-one targeted protein degradation platform guided by degradation condensates-bridging bi-specific nanobodies. Cell Res 34, 389–392 (2024). https://doi.org/10.1038/s41422-024-00942-3
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DOI: https://doi.org/10.1038/s41422-024-00942-3