ABSTRACT
Polycyclic xanthones are secondary metabolites from actinomycetes and cervinomycin A and B are bioactive 26-membered polycyclic xanthones from Streptomyces sp. CPCC 204980. Herein, we report cervinomycins C1-4 (1–4) from the same strain. The structures of 1–4 were determined by 1D- and 2D-NMR, or single-crystal X-ray diffraction. Compounds 1–4 feature the open or loss of A (oxazolidine) ring in their angular polycyclic framework compared with cervinomycin B. Compounds 1–4 showed potent cytotoxicity against human cancer cell lines HCT116 and BxPC-3, with IC50 at 0.9–801.0 nM and strong anti-Gram-positive bacterial activity.
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Acknowledgements
We thank colleagues at the Nuclear Magnetic Resonance Center (Institute of Materia Medica, CAMS & PUMC) and Analytical Center of Drugs (Institute of Medicinal Biotechnology, CAMS & PUMC) for the NMR, MS, and CD analyses. This work was supported by CAMS Initiative for Innovative Medicine (CAMS-I2M-1-012), National Natural Science Foundation of China (81573328), Drug Innovation Major Project (2018ZX09711-001), and National Infrastructure of Microbiological Resources (No. NIMR-2018-3).
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Hu, X., Sun, W., Li, S. et al. Cervinomycins C1-4 with cytotoxic and antibacterial activity from Streptomyces sp. CPCC 204980. J Antibiot 73, 812–817 (2020). https://doi.org/10.1038/s41429-020-0342-1
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DOI: https://doi.org/10.1038/s41429-020-0342-1