Table 3 Effect of probiotics on serum inflammatory factors, chemokines, and intestinal barrier function.

From: Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury

 

NC

PC

LP

HP

Between-group comparisons

P 1

P 2

IL-1β, pg/ml

27.56 ± 6.08

40.17 ± 6.66*

37.27 ± 5.61

36.09 ± 8.41

0.000

0.008

TNF-α, pg/ml

52.91 ± 12.39

103.09 ± 15.39*

101.40 ± 10.15*

98.44 ± 11.43*

0.000

0.041

IL-6, pg/ml

38.67 ± 9.39

208.6 ± 78.31*

203.99 ± 30.77*

141.6 ± 28.60*

0.000

0.000

IL-10, pg/ml

102.04 ± 27.60

82.29 ± 21.46

97.04 ± 32.80

155.63 ± 36.92*

0.000

0.000

RANTES, ng/ml

19.47 ± 6.47

52.56 ± 7.37*

49.35 ± 5.38*

45.82 ± 10.81*

0.000

0.043

MCP-1, pg/ml

77.19 ± 9.15

115.99 ± 20.93*

100.30 ± 10.20

93.13 ± 14.10

0.000

0.001

D-lactates, μg/ml

0.77 ± 0.17

1.48 ± 0.15*

1.37 ± 0.23*

1.24 ± 0.13*

0.000

0.000

Endotoxin, EU/ml

0.03 ± 0.02

0.24 ± 0.01*

0.17 ± 0.01

0.11 ± 0.02

0.000

0.000

I-FABP, ng/ml

109.79 ± 25.19

233.79 ± 49.43*

206.19 ± 39.02*

154.49 ± 29.08

0.000

0.000

DAO, U/ml

21.10 ± 4.49

38.91 ± 5.65*

34.88 ± 4.35*

23.53 ± 3.88

0.000

0.000

  1. Values are presented as mean ± SD. P < 0.05 indicated significantly different between the trial arms
  2. NC normal control group, PC positive control group, LP low dose intervention group, HP high dose intervention group.
  3. * P < 0.05 versus NC group; P 1 value was calculated by a crude general linear model to test the difference in treatment effects between the groups. P 2 value was calculated by a full general linear model with adjustments for age, BMI, the liver function, lipid metabolism, and inflammatory factor to test the difference in treatment effects between the groups.
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