Table 3 Odds ratios and corresponding 95% confidence intervals for family history predictors of BRCA1 and BRCA2 pathogenic variant carrier status

From: Classification of variants of uncertain significance in BRCA1 and BRCA2 using personal and family history of cancer from individuals in a large hereditary cancer multigene panel testing cohort

No. of 1st/2nd relatives

BRCA1

BRCA2

With BC <50 (vs. 0)

Caucasian

African American

Asian

Hispanic

Caucasian

African American

Asian

Hispanic

 1

2.2 (2.0, 2.4)

3.1 (2.2, 4.4)

2.8 (1.7, 4.5)

2.7 (1.9, 3.9)

1.5 (1.3, 1.7)

1.3 (0.9, 1.8)

1.3 (0.8, 2.0)

1.5 (1.0, 2.2)

 2

3.7 (3.1, 4.4)

5.1 (3.2, 8.2)

3.0 (1.3, 7.2)

5.0 (2.9, 8.7)

2.0 (1.6, 2.4)

1.4 (0.8, 2.4)

1.5 (0.7, 3.5)

1.3 (0.7, 2.7)

 3+

5.3 (4.0, 7.0)

12.0 (6.5, 22.1)

8.3 (2.2, 32.1)

9.1 (4.4, 18.9)

3.2 (2.4, 4.3)

1.8 (0.7, 4.5)

3.1 (0.7, 13.9)

3.4 (1.4, 8.2)

BC ≥50 (vs. 0)

        

 1

0.9 (0.8, 1.1)

0.7 (0.5, 1.0)

1.5 (0.9, 2.3)

1.1 (0.7, 1.5)

1.1 (0.9, 1.2)

0.8 (0.6, 1.2)

2.4 (1.6, 3.6)

1.3 (0.9, 1.9)

 2

0.7 (0.6, 0.8)

0.5 (0.2, 1.0)

0.6 (0.2, 2.0)

0.7 (0.4, 1.4)

0.9 (0.8, 1.1)

0.8 (0.5, 1.3)

1.4 (0.6, 3.0)

0.9 (0.5, 1.7)

 3+

0.7 (0.5, 1.0)

0.7 (0.2, 1.9)

2.0 (0.4, 8.8)

0.9 (0.3, 2.7)

0.7 (0.6, 1.0)

1.4 (0.7, 2.6)

3.0 (1.1, 7.8)

0.4 (0.1, 1.6)

OC <60 (vs. 0)

        

 1

3.2 (2.8, 3.7)

1.7 (1.0, 2.9)

3.4 (1.9, 6.2)

1.9 (1.2, 2.9)

1.4 (1.2, 1.7)

2.1 (1.3, 3.2)

1.5 (0.8, 2.8)

1.4 (0.8, 2.2)

 2+

5.4 (4.1, 7.1)

0.4 (0.0, 2.9)

4.8 (1.2, 19.1)

3.0 (1.4, 6.6)

1.4 (0.9, 2.1)

0.6 (0.1, 4.2)

1.0 (0.1, 7.6)

1.0 (0.3, 3.4)

OC ≥60 (vs. 0)

        

 1

1.7 (1.4, 2.0)

2.3 (1.2, 4.1)

1.8 (0.8, 4.1)

1.9 (1.0, 3.6)

1.6 (1.3, 1.8)

0.7 (0.3, 1.5)

1.2 (0.6, 2.6)

1.5 (0.8, 2.9)

 2+

1.6 (0.9, 2.8)

2.7 (0.6, 12.5)

5.6 (1.3, 25.0)

2.0 (0.3, 15.4)

1.9 (1.2, 3.0)

1.0 (0.1, 7.1)

–

1.6 (0.4, 7.0)

Pancreatic cancer

        

 1

1.1 (0.9, 1.3)

0.9 (0.5, 1.6)

0.7 (0.2, 1.9)

1.2 (0.7, 2.3)

1.3 (1.1, 1.5)

1.6 (1.0, 2.5)

1.7 (0.9, 3.1)

2.1 (1.3, 3.3)

 2+

0.7 (0.4, 1.1)

2.0 (0.7, 5.5)

1.3 (0.2, 10.0)

2.6 (1.0, 6.6)

1.7 (1.3, 2.2)

1.1 (0.3, 3.6)

0.6 (0.1, 4.5)

0.4 (0.1, 2.9)

MBC

1.0 (0.7, 1.5)

0.9 (0.2, 3.7)

–

0.4 (0.0, 3.1)

2.5 (1.9, 3.1)

5.4 (3.0, 9.7)

–

3.1 (1.3, 7.5)

Prostate (vs. 0)

        

 1

0.9 (0.8, 1.1)

0.4 (0.2, 0.7)

0.9 (0.4, 1.9)

0.8 (0.5, 1.3)

1.3 (1.2, 1.5)

1.2 (0.8, 1.7)

1.8 (1.1, 3.0)

1.3 (0.8, 2.0)

 2+

0.7 (0.5, 0.9)

0.5 (0.2, 1.1)

0.5 (0.1, 4.3)

0.4 (0.1, 1.4)

1.5 (1.3, 1.8)

0.9 (0.5, 1.6)

1.9 (0.6, 6.7)

2.1 (1.1, 3.9)

Total model AUC

0.79 (0.77–0.80)

0.83 (0.80–0.86)

0.79 (0.74–0.83)

0.82 (0.79–0.85)

0.67 (0.66–0.69)

0.68 (0.64–0.72)

0.70 (0.65–0.75)

0.66 (0.62–0.71)

  1. AUC area under the curve, BC breast cancer, MBC male breast cancer, OC ovarian cancer.
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