Table 1 Descriptive characteristics of the entire cohort (N = 1812)d.

From: Diagnosing hereditary cancer predisposition in men with prostate cancer

 

Total (N)

Total (%)

Age at testing (IQR)

66 (59,73)

 

Race/ethnicity

  African American/Black

109

6.0%

  Ashkenazi Jewish

165

9.1%

  Asian

23

1.3%

  Caucasian

1268

70.0%

  Hispanic

47

2.6%

  Middle Eastern

7

0.4%

  Mixed ethnicity

65

3.6%

  Native American

2

0.1%

  Other

8

0.4%

  Unknown

118

6.5%

Personal history of other cancersa

  Yes

758

41.8%

  No

1054

58.2%

Personal history of other cancersc

  Breast

105

5.8%

  Colorectal

201

11.1%

  Pancreatic

111

6.1%

  Other

487

26.9%

  None

1054

58.2%

Family history of cancerb,c

  Yes

1674

92.4%

  No

138

7.6%

Family history of cancer

  Breast

943

52.0%

  Colorectal

578

31.9%

  Pancreatic

313

17.3%

  Prostate

917

50.6%

  Other

1177

65.0%

Gleason score

  Low (<7)

162

17.7%

  Intermediate (7)

396

43.2%

  High (8–10)

359

39.1%

  Missing

895

 

>1 Family member with breast, ovarian, or pancreatic cancer

  Yes

649

35.8%

  No

1163

64.2%

>1 Family member with Lynch syndrome–related cancer

  Yes

572

31.6%

  No

1240

68.4%

Test ordered

  ProstateNext

284

15.7%

  Other multigene panel tests

1528

84.3%

  1. aCancer status “not provided” and “no” are treated as the same.
  2. bOnly first-, second-, and third-degree relatives are included.
  3. cNonmelanoma skin cancers and unspecified cancers are excluded.
  4. dExcluded 66 probands with a known BRCA1/2 pathogenic variant in the family.