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  • Review Article
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Review of penile reconstructive techniques

Abstract

Reconstructive surgery of the penis holds many unique challenges due to the unique physiological properties of the tissues. Much of the effort involved therefore goes to preserving as much of the native tissue as possible whilst novel and creative methods have been adopted to repair defects and in creation of neophallus. A search of the PubMed database was carried out using the following keywords: ‘penile trauma’, ‘penile cancer’, ‘lichen sclerosus’, ‘glansectomy’, ‘glans resurfacing’, ‘penile-sparing surgery’, ‘micropenis’, ‘aphallia’, ‘female-to-male sex reassignment surgery’, ‘scrotal flap’ and ‘genital lymphoedema’. Results for glans resurfacing in treating cancer showed low local recurrence rates at 0–10% whilst 90% of lichen sclerosus patients reported complete resolutions of pain and pruritis. For repairs of penile shaft skin defects the literature supports the use of full-thickness skin graft and pedicled scrotal flaps. The radial artery-based forearm free flap remains the best option for neophallus creation in terms of function, sensation and cosmesis but unfortunately leaves a disfiguring scar and involves multiple stages. Some novel techniques have been developed to circumvent these issues and are discussed. This article presents an update on the important developments in the field of penile reconstructive surgery.

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Fig. 1: Steps in total glans resurfacing.
Fig. 2: Total glansectomy with neoglans formation.
Fig. 3: Four stages of RAFF phalloplasty.

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References

  1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016;66:7–30.

    PubMed  Google Scholar 

  2. Pizzocaro G, Algaba F, Horenblas S, Solsona E, Tana S, Van Der Poel H, et al. EAU penile cancer guidelines 2009. Eur Urol. 2010;57:1002–12.

    PubMed  Google Scholar 

  3. Brown CT, Minhas S, Ralph DJ. Conservative surgery for penile cancer: subtotal glans excision without grafting. BJU Int. 2005;96:911–2.

    PubMed  Google Scholar 

  4. Depasquale I, Park AJ, Bracka A. The treatment of balanitis xerotica obliterans: the treatment of Bxo. BJU Int. 2000;86:459–65.

    CAS  PubMed  Google Scholar 

  5. Hadway P, Corbishley CM, Watkin NA. Total glans resurfacing for premalignant lesions of the penis: initial outcome data. BJU Int. 2006;98:532–6.

    PubMed  Google Scholar 

  6. O’Kelly F, Lonergan P, Lundon D, Nason G, Sweeney P, Cullen I, et al. A prospective study of total glans resurfacing for localized penile cancer to maximize oncologic and functional outcomes in a tertiary referral network. J Urol. 2017;197:1258–63.

    PubMed  Google Scholar 

  7. Shabbir M, Muneer A, Kalsi J, Shukla CJ, Zacharakis E, Garaffa G, et al. Glans resurfacing for the treatment of carcinoma in situ of the penis: surgical technique and outcomes. Eur Urol. 2011;59:142–7.

    PubMed  Google Scholar 

  8. Philippou P, Shabbir M, Malone P, Nigam R, Muneer A, Ralph DJ, et al. Conservative surgery for squamous cell carcinoma of the penis: resection margins and long-term oncological control. J Urol. 2012;188:803–8.

    PubMed  Google Scholar 

  9. Pietrzak P, Corbishley C, Watkin N. Organ-sparing surgery for invasive penile cancer: early follow-up data. BJU Int. 2004;94:1253–7.

    PubMed  Google Scholar 

  10. Morelli G, Pagni R, Mariani C, Campo G, Menchini-Fabris F, Minervini R, et al. Glansectomy with split-thickness skin graft for the treatment of penile carcinoma. Int J Impot Res. 2009;21:311–4.

    CAS  PubMed  Google Scholar 

  11. Malone PR, Thomas JS, Blick C. A tie-over dressing for graft application in distal penectomy and glans resurfacing: the TODGA technique. BJU Int. 2011;107:836–40.

    PubMed  Google Scholar 

  12. Sedigh O, Falcone M, Ceruti C, Timpano M, Preto M, Oderda M, et al. Sexual function after surgical treatment for penile cancer: Which organ-sparing approach gives the best results? Can Urol Assoc J. 2015;9:423.

    Google Scholar 

  13. Gulino G, Sasso F, Falabella R, Bassi PF. Distal urethral reconstruction of the glans for penile carcinoma: results of a novel technique at 1-year of followup. J Urol. 2007;178:941–4.

    CAS  PubMed  Google Scholar 

  14. Algaba F, Arce Y, López-Beltrán A, Montironi R, Mikuz G, Bono AV. Intraoperative frozen section diagnosis in urological oncology. Eur Urol. 2005;47:129–36.

    CAS  PubMed  Google Scholar 

  15. Kamel MH, Bissada N, Warford R, Farias J, Davis R. Organ sparing surgery for penile cancer: a systematic review. J Urol. 2017;198:770–9.

    PubMed  Google Scholar 

  16. Hegarty PK, Shabbir M, Hughes B, Minhas S, Perry M, Watkin N, et al. Penile preserving surgery and surgical strategies to maximize penile form and function in penile cancer: recommendations from the United Kingdom experience. World J Urol. 2009;27:179–87.

    PubMed  Google Scholar 

  17. Baumgarten AS, Fisher JS, Lawindy SM, Pavlinec JG, Carrion RE, Spiess PE. Penile sparing surgical approaches for primary penile tumors: preserving function and appearance. Transl Androl Urol. 2017 ;6:809–19.

    PubMed  PubMed Central  Google Scholar 

  18. Djajadiningrat RS, van Werkhoven E, Meinhardt W, van Rhijn BWG, Bex A, van der Poel HG, et al. Penile sparing surgery for penile cancer—does it affect survival? J Urol. 2014;192:120–6.

    PubMed  Google Scholar 

  19. Garaffa G, Christopher N, Ralph DJ. The management of genital lymphoedema. BJU Int. 2008;102:480–4.

    PubMed  Google Scholar 

  20. Shim TN, Doiron PR, Francis N, Minhas S, Muneer A, Hawkins D, et al. Penile lymphoedema: approach to investigation and management. Clin Exp Dermatol. 2019;44:20–31.

    CAS  PubMed  Google Scholar 

  21. Garaffa G, Raheem AA, Ralph DJ. An update on penile reconstruction. Asian J Androl. 2011;13:391–4.

    PubMed  PubMed Central  Google Scholar 

  22. Jeong JH, Shin HJ, Woo SH, Seul JH. A new repair technique for penile paraffinoma: bilateral scrotal flaps. Ann Plast Surg. 1996;37:386–93.

    CAS  PubMed  Google Scholar 

  23. Fakin R, Zimmermann S, Jindarak S, Lindenblatt N, Giovanoli P, Suwajo P. Reconstruction of penile shaft defects following silicone injection by bipedicled anterior scrotal flap. J Urol. 2017;197:1166–70.

    PubMed  Google Scholar 

  24. Li C-Y, Kayes O, Kell PD, Christopher N, Minhas S, Ralph DJ. Penile suspensory ligament division for penile augmentation: indications and results. Eur Urol. 2006;49:729–33.

    PubMed  Google Scholar 

  25. Morrison SD, Shakir A, Vyas KS, Kirby J, Crane CN, Lee GK. Phalloplasty: a review of techniques and outcomes. Plast Reconstr Surg. 2016;138:594–615.

    CAS  PubMed  Google Scholar 

  26. Wierckx K, Van Caenegem E, Elaut E, Dedecker D, Van de Peer F, Toye K, et al. Quality of life and sexual health after sex reassignment surgery in transsexual men. J Sex Med. 2011;8:3379–88.

    PubMed  Google Scholar 

  27. Bogoraz NA. On complete plastic reconstruction of a penis sufficient for coitus. Sov Surg. 1936;8:303–9.

    Google Scholar 

  28. Nair R, Sriprasad S. 1129 Sir Harold Gillies: pioneer of phalloplasty and the birth of uroplastic surgery. J Urol. 2010;183(4S). https://doi.org/10.1016/j.juro.2010.02.2326.

  29. Chang T-S, Hwang W-Y. Forearm flap in one-stage reconstruction of the penis. Plast Reconstr Surg. 1984 ;74:251–8.

    CAS  PubMed  Google Scholar 

  30. Song R, Gao Y, Song Y, Yu Y, Song Y. The forearm flap. Clin Plast Surg. 1982;9:21–6.

    CAS  PubMed  Google Scholar 

  31. Garaffa G, Christopher NA, Ralph DJ. Total phallic reconstruction in female-to-male transsexuals. Eur Urol. 2010;57:715–22.

    PubMed  Google Scholar 

  32. Ascha M, Massie JP, Morrison SD, Crane CN, Chen ML. Outcomes of single stage phalloplasty by pedicled anterolateral thigh flap versus radial forearm free flap in gender confirming surgery. J Urol. 2018 ;199:206–14.

    PubMed  Google Scholar 

  33. Monstrey S, Hoebeke P, Dhont M, Selvaggi G, Hamdi M, Van Landuyt K, et al. Radial forearm phalloplasty: a review of 81 cases. Eur J Plast Surg. 2005;28:206–12.

    Google Scholar 

  34. Baumeister S, Sohn M, Domke C, Exner K. Phallusbildung beim Frau-zu-Mann Transsexuellen: Erfahrung in 259 Fällen. Handchir Mikrochir Plast Chir. 2011;43:215–21.

    CAS  PubMed  Google Scholar 

  35. Heston AL, Esmonde NO, Dugi III DD, Berli JU. Phalloplasty: techniques and outcomes. Transl Androl Urol. 2019;8(Jun):254–65.

    PubMed  PubMed Central  Google Scholar 

  36. Garaffa G, Ralph DJ, Christopher N. Total urethral construction with the radial artery-based forearm free flap in the transsexual: creation of a sensate neourethra in female-to-male transsexuals. BJU Int. 2010;106:1206–10.

    PubMed  Google Scholar 

  37. Selvaggi G, Monstrey S, Hoebeke P, Ceulemans P, Van Landuyt K, Hamdi M, et al. Donor-site morbidity of the radial forearm free flap after 125 phalloplasties in gender identity disorder. Plast Reconstr Surg. 2006;118:1171–7.

    CAS  PubMed  Google Scholar 

  38. Felici N, Felici A. A new phalloplasty technique: the free anterolateral thigh flap phalloplasty. J Plast Reconstr Aesthet Surg. 2006;59:153–7.

    CAS  PubMed  Google Scholar 

  39. D’Arpa S, Claes K, Lumen N, Oieni S, Hoebeke P, Monstrey S. Urethral reconstruction in anterolateral thigh flap phalloplasty: a 93-case experience. Plast Reconstr Surg. 2019;143:382e–92e.

    PubMed  Google Scholar 

  40. Bettocchi C, Ralph DJ, Pryor JP. Pedicled pubic phalloplasty in females with gender dysphoria. BJU Int. 2005;95:120–4.

    PubMed  Google Scholar 

  41. Kocjancic E, Jaunarena JH, Schechter L, Acar Ö. Inflatable penile prosthesis implantation after gender affirming phalloplasty with radial forearm free flap. Int J Impot Res. 2019; http://www.nature.com/articles/s41443-019-0153-8.

  42. Falcone M, Garaffa G, Gillo A, Dente D, Christopher AN, Ralph DJ. Outcomes of inflatable penile prosthesis insertion in 247 patients completing female to male gender reassignment surgery. BJU Int. 2018;121:139–44.

    CAS  PubMed  Google Scholar 

  43. Neuville P, Morel-Journel N, Maucourt-Boulch D, Ruffion A, Paparel P, Terrier J-E. Surgical outcomes of erectile implants after phalloplasty: retrospective analysis of 95 procedures. J Sex Med. 2016;13:1758–64.

    PubMed  Google Scholar 

  44. Hoebeke PB, Decaestecker K, Beysens M, Opdenakker Y, Lumen N, Monstrey SM. Erectile implants in female-to-male transsexuals: our experience in 129 patients. Eur Urol. 2010;57:334–41.

    PubMed  Google Scholar 

  45. Schlenker B, Tilki D, Gratzke C, Seitz M, Reich O, Schneede P, et al. Intermediate-differentiated invasive (pT1 G2) penile cancer—oncological outcome and follow-up. Urol Oncol Semin Orig Investig. 2011;29:782–7.

    Google Scholar 

  46. Ayres BE, Lam W, Al-Najjar HM, Corbishley CM, Perry MJA, Watkin NA. 1106 glans resurfacing—a new penile preserving option for superficially invasive penile cancer. Eur Urol. 2011;10(Suppl 2):340.

    Google Scholar 

  47. Garaffa G, Shabbir M, Christopher N, Minhas S, Ralph DJ. The surgical management of Lichen Sclerosus of the glans penis: our experience and review of the literature. J Sex Med. 2011;8:1246–53.

    PubMed  Google Scholar 

  48. Håkansson U, Kirrander P, Uvelius B, Baseckas G, Torbrand C. Organ-sparing reconstructive surgery in penile cancer: initial experiences at two Swedish referral centres. Scand J Urol. 2015;49:149–54.

    PubMed  Google Scholar 

  49. Chipollini J, Yan S, Ottenhof SR, Zhu Y, Draeger D, Baumgarten AS, et al. Surgical management of penile carcinoma in situ: results from an international collaborative study and review of the literature. BJU Int. 2018 ;121:393–8.

    PubMed  Google Scholar 

  50. O’Kane HF, Pahuja A, Ho KJ, Thwaini A, Nambirajan T, Keane P. Outcome of glansectomy and skin grafting in the management of penile cancer. Adv Urol. 2011;2011:1–4.

    Google Scholar 

  51. Palminteri E, Berdondini E, Lazzeri M, Mirri F, Barbagli G. Resurfacing and reconstruction of the glans penis. Eur Urol. 2007;52:893–900.

    PubMed  Google Scholar 

  52. Smith Y, Hadway P, Biedrzycki O, Perry MJA, Corbishley C, Watkin NA. Reconstructive surgery for invasive squamous carcinoma of the glans penis. Eur Urol. 2007;52:1179–85.

    PubMed  Google Scholar 

  53. Veeratterapillay R, Sahadevan K, Aluru P, Asterling S, Rao GS, Greene D. Organ-preserving surgery for penile cancer: description of techniques and surgical outcomes: organ-preserving surgery for penile cancer. BJU Int. 2012;110:1792–5.

    PubMed  Google Scholar 

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Correspondence to David Ralph.

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Kristinsson, S., Johnson, M. & Ralph, D. Review of penile reconstructive techniques. Int J Impot Res 33, 243–250 (2021). https://doi.org/10.1038/s41443-020-0246-4

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