Fig. 8
From: Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
Schematic illustration of the tanycyte effects on TRH release in the ME. Activation of hypophysiotropic TRH neurons in the PVN (1) leads to TRH release in the ME (2). TRH stimulates the TRHR1-dependent Gα q/11 pathway, which results in activation of the phospholipase C and increase in [Ca2+]i (3). Activation of the tanycytic Gα q/11 pathway enlarges tanycytic endfeet, which may retain TRH in the ME (4) and increases the time for degradation of TRH by the upregulated TRH-DE. Overall, activation of tanycytic Gαq/11 signaling results in a downregulation of the TRH release into the pituitary vessels (5)
