Fig. 1 | Nature Communications

Fig. 1

From: One-step fermentative production of aromatic polyesters from glucose by metabolically engineered Escherichia coli strains

Fig. 1

Metabolic engineering of E. coli for the production of aromatic PHAs. The overall strategies for the production of aromatic PHAs are shown. Blue boxes represent heterologous and endogenous enzymes introduced for the construction of metabolic pathways for aromatic PHAs. The orange and purple boxes indicate CoA-transferase and PHA synthase, respectively. The inactivated metabolic pathways are indicated by “X”. Dotted lines indicate feedback inhibition. DAHP, 3-deoxy-d-arabino-heptulosonate-7-phosphate; E4P, erythrose-4-phosphate; 3HB-CoA, 3-hydroxybutyryl-CoA; 3HPh, d-3-hydroxy-3-phenylpropionate; 3HPh-CoA, d-3-hydroxy-3-phenylpropionyl-CoA; 4HPLA, d-4-hydroxyphenyllactate; 4HPLA-CoA, d-4-hydroxyphenyllactyl-CoA; l-Phe, l-phenylalanine; l-Tyr, l-tyrosine; PhLA, d-phenyllactate; MA, d-mandelate; MA-CoA, d-mandelyl-CoA; PhLA-CoA, d-phenyllactatyl-CoA; PEP, phosphoenolpyruvate; SHIK, shikimate; S3P, shikimate-3-phosphate

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