Fig. 4
From: Gene-by-environment interactions in urban populations modulate risk phenotypes
NO2 exposure modulates the effect of the top genetic variant rs10156534 on smarca2 expression. a The expression level of smarca2, an ATP-dependant helicase involved in several cancers, is modulated by the genotype at rs10156534 and NO2 exposition levels. b SMARCA2 is part of a highly connected gene network, the SNF/SWI complex, which acts to remodel chromatin structure and is required to activate transcription of repressed genes. c Several enhancers around smarca2 are found nearby or at location where eSNPs were significant for an interaction with pollution. The upper whiskers extend from the third quartile to the largest value no further than 1.5 * inter-quartile range from the third quartile. The lower whiskers extend from the first quartile to the smallest value at most 1.5 * inter-quartile range from the first quartile
