Table 4 Results of GWAS of NVP as an ordinal response (SCAN2) with p < 5 × 10−8. The directions of effect correspond to the minor allele, listed second
From: Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum
Cytoband | Marker | Position | Alleles | MAF | p-value | β | 95% CI | SCAN1 p-value | SCAN1 OR | SCAN1 95% CI | Gene context |
|---|---|---|---|---|---|---|---|---|---|---|---|
19p13.11 | rs16982345 | 19:18500722 | G/A | 0.25 | 2.4 × 10−41 | −0.104 | [−0.120, −0.089] | 6.81 × 10−15 | 0.68 | [0.615, 0.751] | GDF15[]-LRRC25 |
4q12 | rs143409503 | 4:58351064 | −/AGC | 0.34 | 9.2 × 10−24 | −0.072 | [−0.086,−0.058] | 1.86 × 10−10 | 0.752 | [0.688, 0.822] | IGFBP7—[] |
11q22.1 | rs2508362 | 11:101260798 | A/G | 0.199 | 1.7 × 10−12 | 0.06 | [0.043,0.076] | 1.06 × 10−04 | 0.819 | [0.741, 0.904] | PGR—[]–TRPC6 |
6q15 | rs4707680 | 6:92294371 | T/C | 0.427 | 2.8 × 10−10 | 0.043 | [0.030, 0.056] | 5.79 × 10−02 | 0.924 | [0.851, 1.00] | MAP3K7-[] |
22q11.23 | rs201838815 | 22:24753023 | T/− | 0.02 | 5.8 × 10−9 | −0.159 | [−0.212, −0.105] | 2.88 × 10−02 | 0.685 | [0.480, 0.979] | [SPECC1L,SPECCl-ADORA2A] |
6p12.1 | rs7761177 | 6:55151343 | T/C | 0.495 | 6.2 × 10−9 | −0.039 | [−0.052, −0.026] | 1.70 × 10−06 | 0.82 | [0.755, 0.889] | HCRTR2-[]–GFRAL |
4q31.21 | rs4690766 | 4:144030040 | G/C | 0.358 | 1.3 × 10−8 | −0.04 | [−0.054, −0.026] | 1.02 × 10−01 | 0.932 | [0.856, 1.01] | INPP4B—[]–USP38 |
