Fig. 5

Summary of inflammation-associated functional connectivity changes. a Nodes and edges showing the Network-Based Statistic (NBS) inflammation configuration, with scatterplot showing the association (Pearson correlation) between erythrocyte sedimentation rate (ESR) and the average strength of connectivity across the 54 edges. Undirected and weighted Fisher z-transformed bivariate correlation matrices of connectivity were created for each subject from 10 mm diameter spheres at the 264 nodes of the Power atlas (264 × 264 matrices). Identified nodes and edges associated in aggregate with higher ESR are derived from permutation testing at family wise error corrected p < 0.05. b Overlap of regions of positive connectivity identified through seed network to whole-brain analyses and nodes identified through NBS analyses of higher inflammation