Table 1 OR2AT4 stimulation by Sandalore® treatment regulates different signaling protein phosphorylation pathways in human HFs ex vivo
Proteins regulated under 50 µM Sandalore stimulation | Type of regulation | Proteins regulated under 500 µM Sandalore stimulation | Type of regulation |
|---|---|---|---|
p38α (T180/Y182) | ↑(2,5) | p38α (T180/Y182) | ↑(1,8) |
ERK1/2 (T202/Y204, T185/Y187) | ↑(1,9) | ERK1/2 (T202/Y204, T185/Y187) | ↑(1,8) |
EGFR (Y1086) | ↑(3,2) | EGFR (Y1086) | ↑(2,6) |
MSK1/2 (S376/S360) | ↑(2,1) | MSK1/2 (S376/S360) | ↑(2,1) |
PYK2 (Y402) | ↑(4,7) | PYK2 (Y402) | ↑(2,2) |
Hsp60 | ↓(0,6) | ||
JNK 1/2/3 (T183/Y185, T221/Y223) | ↑(2,2) | ||
AMPKα1 (T183) | ↑(2,0) | ||
PLC-γ1 (Y783) | ↑(2,4) | ||
Fgr (Y421) | ↑(1,9) | ||
PRAS40 (T246) | ↑(1,9) | ||
p53 (S392) | ↓(0,5) | ||
p53 (S46) | ↓(0,6) | ||
p53 (S15) | ↓(0,5) |
