Fig. 4
From: NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation
A novel mouse model to study the sequential progression from plexiform neurofibroma to MPNST. a, b Representative gross image of a PLPCreERT2; Nf1f/f mouse that develops MPNST in the right sciatic nerve and b its dissected spinal cord along with peripheral nerves. c–f Representative c X-Gal staining (PLPCreERT2; Nf1f/f; ROSA-LacZ), IHC using d S100 and e H3K27 (arrow head) antibodies and f H&E in histological sections of dissected MPNST from PLPCreERT2; Nf1f/f. Scale bar is equal to 50 μm
