Fig. 2 | Nature Communications

Fig. 2

From: Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

Fig. 2

Engagement of GITR protects from the onset of Type 2 Diabetes. a A cohort of C57/BL6 mice fed a normal chow diet (NCD) or a high fat diet (HFD) were either treated with DTA-1 (1 mg/mouse) or isotype control by intraperitoneal injections every four days according to the scheme, n = 8. b Total weight and c fasting blood glucose levels were measured every two weeks for 14 weeks. Glucose tolerance test (d) and insulin tolerance test (e) were performed in a cohort of C57BL/6 mice fed a NCD or a HFD and treated for 14 weeks with or without DTA-1. The corresponding area under the curve was calculated for each group. Time-kinetic qPCR expression of IL-33 (f) and IL-25 (g) on VAT lysates. Error bars are the mean ± SEM. Student’s t-test, **p < 0.01, ***p < 0.001, ns, non-significant. Mouse image provided with permission from Servier Medical Art

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