Fig. 7
From: A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates
Hoxa2 and Hoxb2 enhancers exhibit differential TALE (Three-Amino-Acid-Loop-Extension) and Hox binding correlating with their tissue-specific activities. a DNA-binding profiles for Hox, TALE, and p300 factors in neural cell culture and pharyngeal arch 2 tissues at the mouse Hoxa2 (NC3) and Hoxb2 (HRE) neural crest (NC) enhancers (highlighted in purple). Genes are annotated (top) and are transcribed from left-to-right. b Summary diagram of characterized differential regulatory inputs (purple arrows) from Hox and TALE factors (inferred from a) into the mouse Hoxa2 and Hoxb2 NC enhancers in pharyngeal arch 2 (NC) and hindbrain r4 in vivo. Activation or inactivation of transcription is depicted by green arrows or a black cross, respectively. Purple arrows from the Hoxa2 gene indicate auto-/cross-regulation
