Fig. 2
From: Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue
Cryo-EM structure of fibril morphology I. a Representative cryo-EM micrograph indicating fibril morphologies I and II. Asterisk: morphology I-like fibril emanating from morphology II. Scale bar: 50 nm. b Side view of the reconstructed 3D map. c Cross-sectional view of one molecular layer of the fibril superimposed with the molecular model. d Side view of the 3D map of a six-layer peptide stack superimposed with the molecular model. The stack is viewed along the red arrow head in panel (c). e Side view of six molecular layers of the boxed region from panel (c), viewed along the black arrow head. The figure illustrates the staggering of the two peptide stacks. The two peptide stacks are colored gray and blue in panels (b–d)
