Fig. 3
From: Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue
Peptide fold of fibril morphology I. a Ribbon diagram of six layers of the fibril. b Location of β-strands β1–β4 within the Aβ(1−40) sequence. Mutations are shown in magenta. c Top view of a peptide stack showing the right-hand β-sheet twist. Only every sixth molecule shown. d Section of the Ramachandran plot showing the Φ/Ψ-pairs of the residues within β-strands β1−β4. The β-strand color coding is kept consistent in panels (a–d). e Packing scheme of one molecular layer of the fibril. f Cross-sectional view of the fibril with the known mutational variants highlighted in magenta (3)
