Table 1 Clinical information on PBMC and plasma sample donors.
PBMC | Plasma | ||||||
|---|---|---|---|---|---|---|---|
NT1 patients (all) | NT1 patients (Discovery cohort) | NT1 patients (Validation cohort) | Healthy controls | NT1 patients | Healthy vaccinated controls | Healthy unvaccinated controls | |
Number of subjects | 28 | 20 | 14 | 33 | 47 | 57 | 130 |
Vaccinated with Pandemrix (%) | 100 | 100 | 100 | 100 | 100 | 100 | 0 |
Age at vaccination (years), median (range) | 11.5 (5.1–20.9) | 11.1 (5.1–20.9) | 11.5 (6.9–18.6) | 8.5 (4.1–16.4) | 11.7 (4.4–16.6) | 7.5 (0.9– 14.8) | n/a |
Age at vaccination (years), mean | 11.8 | 11.1 | 12.5 | 9.0 | 11.4 | 8.3 | n/a |
Age at sampling (years), median (range) | 15.1 (7.7–23.1) | 13.4 (7.7–23.1) | 15.4 (10.9–23.1) | 9.8 (5.5–18.7) | 13.0 (5.9–17.9) | 9.0 (1.4–16.5) | 11.0 (4.0–18.0) |
Time between vaccination and sampling (days), median | 1078 | 805 | 1640 | 527 | 550 | 516 | n/a |
HLA DQB1*06:02 genotype, N (%) | 28 (100) | 21 (100) | 14 (100) | 14 (42.4) | 47 (100) | 21 (36.8) | 68 (52.3) |
Gender, female, N (%) | 18 (64.3) | 11 (52.4) | 9 (64.2) | 19 (57.6) | 28 (59.6) | 30 (52.6) | 61 (46.9) |
