Table 3 A summary of available evidence for the association between molecular alterations and IDHi resistance, including the result from the current study.

Primary resistance

 Leukemia stemness

Current study

 RUNX1 mutations

Current study

 NRAS mutations

Amatangelo et al.⁹, Choe et al.²³

 PTPN11 mutations

Choe et al.²³

 FLT3 mutations (likely)

Choe et al.²³, current study

 Second-site IDH mutations

Intlekofer et al.¹⁶, Choe et al.²³

 IDH homolog switch

Harding et al.¹⁷, Quek et al.¹⁵, Choe et al.²³, current study

 RTK gene mutations (RAS, FLT3, PTPN11, KIT, and others)

Quek et al.¹⁵, Choe et al.²³, current study

 Differentiation gene mutations (RUNX1, GATA2, and CEBPA)

Quek et al.¹⁵, Choe et al.²³, current study

 TET2 mutations

Choe et al.²³, current study

 BCOR mutations

Quek et al.¹⁵, current study