Fig. 3
From: The rumen microbiome: an underexplored resource for novel antimicrobial discovery
Mode of action studies of Lynronne-1, Lynronne-2 and Lynronne-3 against MRSA: a Membrane permeabilization activity against MRSA USA300 measured by propidium iodide assay at 10 min. b Dose-dependent interaction of peptides with total MRSA lipid extract, the initial surface pressure of lipid monolayer being 30 ± 0.5 mN/m. c Interaction of peptides (at 1 µg/ml final concentration) with pure lipids-maximal variation of surface pressure induced by the injection of peptide in lipid monolayer with initial surface pressure of 30 ± 0.5 mN/m. d peptide stability/degradation in 25% serum over time. Relative peptide concentrations were determined by integration of the peaks from RP-HPLC chromatograms (values from three independent replicates; error bars represent one standard deviation)
