Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CELL CULTURE

Organ-specific metastases

A tissue-decellularization method enables the culture of organ-specific metastases on a dish.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Biomatrix scaffolds increase the invasive capacities of colon cancer cells.

References

  1. Yaeger, R. et al. Cancer Cell 33, 125–136.e3 (2018).

    Article  CAS  Google Scholar 

  2. Hynes, R. O. Science 326, 1216–1219 (2009).

    Article  CAS  Google Scholar 

  3. Tian, X. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0231-0 (2018).

    Article  CAS  Google Scholar 

  4. Bissell, M. J. & Hines, W. C. Nat. Med. 17, 320–329 (2011).

    Article  CAS  Google Scholar 

  5. Sung, C. O. et al. Mod. Pathol. 21, 1533–1541 (2008).

    Article  Google Scholar 

  6. Pavlovic, M. et al. J. Natl Cancer Inst. 107, djv256 (2015).

    Article  Google Scholar 

  7. Morales, M. et al. EMBO Mol. Med. 6, 865–881 (2014).

    Article  CAS  Google Scholar 

  8. Tarragona, M. et al. J. Biol. Chem. 287, 21346–21355 (2012).

    Article  CAS  Google Scholar 

  9. Gupta, G. P. et al. Nature 446, 765–770 (2007).

    Article  CAS  Google Scholar 

  10. Urosevic, J. et al. Nat. Cell Biol. 16, 685–694 (2014).

    Article  CAS  Google Scholar 

  11. Urosevic, J., Nebreda, A. R. & Gomis, R. R. Cell Cycle 13, 2641–2642 (2014).

    Article  CAS  Google Scholar 

  12. Jung, P. et al. Stem Cell Rep. 5, 979–987 (2015).

    Article  CAS  Google Scholar 

  13. Eckhardt, B. L., Francis, P. A., Parker, B. S. & Anderson, R. L. Nat. Rev. Drug Discov. 11, 479–497 (2012).

    Article  CAS  Google Scholar 

  14. Barcellos-Hoff, M. H., Lyden, D. & Wang, T. C. Nat. Rev. Cancer 13, 511–518 (2013).

    Article  CAS  Google Scholar 

  15. Mayorca-Guiliani, A. E. et al. Nat. Med. 23, 890–898 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Roger R. Gomis.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Urosevic, J., Gomis, R.R. Organ-specific metastases. Nat Biomed Eng 2, 347–348 (2018). https://doi.org/10.1038/s41551-018-0249-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-018-0249-3

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer