Polymer-coated gold nanoparticles carrying the CRISPR components for knocking out, in the striatum of adult mice with fragile X syndrome, a gene implied in the syndrome’s pathophysiology rescue the mice from the exaggerated repetitive behaviours characteristic of the syndrome’s phenotype.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$99.00 per year
only $8.25 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bagni, C. & Greenough, W. T. Nat. Rev. Neurosci. 6, 376–387 (2005).
Ji, N. Y. & Findling, R. L. Curr. Opin. Psychiatr. 29, 103–125 (2016).
Lee, B. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0252-8 (2018).
Jinek, M. et al. Science 337, 816–821 (2012).
Cong, L. et al. Science 339, 819–823 (2013).
Mali, P. et al. Science 339, 823–826 (2013).
Sun, W. J. et al. Angew. Chem. Int. Ed. 54, 12029–12033 (2015).
Lee, K. et al. Nat. Biomed. Eng. 1, 889–901 (2017).
Gao, X. et al. Nature 553, 217–221 (2018).
Staahl, B. T. et al. Nat. Biotechnol. 35, 431–434 (2017).
Dolen, G. & Bear, M. F. J. Physiol. 586, 1503–1508 (2008).
Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A. & Liu, D. R. Nature 533, 420–424 (2016).
Gaudelli, N. M. et al. Nature 551, 464–471 (2017).
Cox, D. B. T. et al. Science 358, 1019–1027 (2017).
Tsai, S. Q. et al. Nat. Methods 14, 607–614 (2017).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Li, Y., Glass, Z. & Xu, Q. Rescued from the fate of neurological disorder. Nat Biomed Eng 2, 469–470 (2018). https://doi.org/10.1038/s41551-018-0267-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41551-018-0267-1