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CANCER IMMUNOTHERAPY

Combined local and systemic attacks

Intratumoral injection of a hydrogel impregnated with radioisotope-labelled catalase and an immunostimulant, along with systemic immune checkpoint blockade, inhibits tumour growth in mouse models of localized cancer and metastatic cancer.

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Fig. 1: Mechanisms supporting the antitumour immune responses induced by 131I-Cat/CpG/ALG-based radioimmunotherapy in combination with immune checkpoint blockade.

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Correspondence to Charles G. Drake.

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Spina, C.S., Drake, C.G. Combined local and systemic attacks. Nat Biomed Eng 2, 564–565 (2018). https://doi.org/10.1038/s41551-018-0277-z

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