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Sensitive sensing of biomarkers in interstitial fluid

Nature Biomedical Engineering volume 5, pages 3–5 (2021)Cite this article

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A minimally invasive microneedle patch detects specific protein biomarkers in dermal interstitial fluid at high sensitivity via a needle-integrated immunoassay coupled with an ultrabright fluorescent label.

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Fig. 1: Microneedle patch for the detection of biomarkers in ISF.
Fig. 2: Strategies for the sampling of biomarkers in ISF.

References

  1. Yager, P., Domingo, G. J. & Gerdes, J. Annu. Rev. Biomed. Eng. 10, 107–144 (2008).

    Article  CAS  Google Scholar 

  2. Tran, B. Q. et al. J. Proteome Res. 17, 479–485 (2018).

    Article  CAS  Google Scholar 

  3. Samant, P. P. et al. Sci. Transl. Med. 12, eaaw0285 (2020).

    Article  CAS  Google Scholar 

  4. Miller, P. R. et al. Commun. Biol. 1, 173 (2018).

    Article  Google Scholar 

  5. Wang, Z. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-020-00672-y (2021).

  6. Luan, J. et al. Nat. Biomed. Eng. 4, 518–530 (2020).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Tamada, J. A. et al. JAMA 282, 1839–1844 (1999).

    Article  CAS  Google Scholar 

  8. Jina, A. et al. J. Diabetes Sci. Technol. 8, 483–487 (2014).

    Article  CAS  Google Scholar 

  9. Venugopal, M., Arya, S. K., Chornokur, G. & Bhansali, S. A. Sens. Actuators A Phys. 172, 154–160 (2011).

    Article  CAS  Google Scholar 

  10. Kolluru, C., Williams, M., Chae, J. & Prausnitz, M. R. Adv. Healthc. Mater. 8, e1801262 (2019).

    Article  Google Scholar 

  11. Zheng, M. et al. Adv. Healthc. Mater. 9, e1901683 (2020).

    Article  Google Scholar 

  12. Muller, D. A., Corrie, S. R., Coffey, J., Young, P. R. & Kendall, M. A. Anal. Chem. 84, 3262–3268 (2012).

    Article  CAS  Google Scholar 

  13. Zhang, X. X., Chen, G. P., Bian, F. K., Cai, L. J. & Zhao, Y. J. Adv. Mater. 31, 1902825 (2019).

    Article  Google Scholar 

  14. Sharma, S. et al. Anal. Methods 10, 2088–2095 (2018).

    Article  CAS  Google Scholar 

  15. Yu, J. C. et al. Nat. Biomed. Eng. 4, 499–506 (2020).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA

    Youngeun Kim & Mark R. Prausnitz

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  1. Youngeun Kim
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  2. Mark R. Prausnitz
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Correspondence to Mark R. Prausnitz.

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Competing interests

M.R.P. is an inventor of patents licensed to companies developing microneedle-based products, a paid advisor to companies developing microneedle-based products, and a founder or shareholder of companies developing microneedle-based products (Micron Biomedical). These potential competing interests have been disclosed and are managed by Georgia Tech.

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Kim, Y., Prausnitz, M.R. Sensitive sensing of biomarkers in interstitial fluid. Nat Biomed Eng 5, 3–5 (2021). https://doi.org/10.1038/s41551-020-00679-5

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