Influenza vaccine strain selection is informed by international efforts to track antigenic change, focusing on the viral hemagglutinin protein. Recent research advocates monitoring neuraminidase for immune escape mutations that could reduce vaccine efficacy.
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Fox, A., Carolan, L. Neuraminidase escape attempts. Nat Microbiol 4, 2031–2032 (2019). https://doi.org/10.1038/s41564-019-0615-2
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DOI: https://doi.org/10.1038/s41564-019-0615-2